jutearmy28

The primary outcome of the study was a change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale (VAS). As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. The results revealed a statistically significant improvement in activity-related pain intensity in the verum group compared with placebo. (ΔVASBCP = 19 ± 2; ΔVASPlacebo = 13 ± 2; p = 046). The results were confirmed by the physician's assessment. (ΔVASBCP = 16 ± 1; ΔVASPlacebo = 12 ± 1; p = 021). Pain under resting conditions was also improved, but no significance compared with placebo was detected (ΔVASBCP = 10 ± 18; ΔVASPlacebo = 7 ± 15; p = 009). Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after BCP intake. The study demonstrated that the supplementation of specific collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity-related joint pain.[Observations on the change, produced by aging, in double refractivity and trypsin resistance of the collagenous fibers of scar tissue].[Our experience with the application of collagen-based preparations in reconstructive surgery of the middle ear].Kulakova LA, Eremeeva KV, Triakina EG, Lopatin AS, Ovchinnikov IuM. This paper summarizes our experience with the application of collagen-based preparations for reconstructive surgery of the middle ear. The best morphological results (886%) were obtained by the closure of extensive defects with the Oblecolum membrane as a temporary supporting structure and the outer atraumatic dressing for the tympanic transplant (in 30 patients) or by the use of the compact-porous explants from the “Sanguicol” preparation as an overlay on the transplant (in 22 patients). Twenty seven patients presenting with the so-called “operated ear disease” underwent mastoidoplasty with the use of the compact-porous preparation “Stimul-oss” as a supporting structure to induce the ingrowth of the bone tissue and the subsequent substitution of the defect. This treatment ensured the reduction of the volume of the bony trepanation cavity. In addition, we have obtained preliminary encouraging results of the application of collagene preparations for the surgical intervention on the stirrup in the Metabolites of type I, II, III, and IV collagen may serve as markers of disease Medicine Charles University in Prague, Na Slupi 4, Prague, 128 50, Czech Medicine Charles University in Prague, Na Slupi 4, Prague, 128 50, Czech Local inflammation in axial spondyloarthritis (axSpA) leads to the release of collagen metabolites from the disease-affected tissue. We investigated whether collagen metabolites were associated with disease activity and could distinguish non-radiographic(nr)-axSpA from ankylosing spondylitis (AS). A total of 193 axSpA patients (nr-axSpA, n = 121 and AS, n = 72) and asymptomatic controls (n = 100) were included. Serum levels of metalloproteinase (MMP)-degraded collagen type I (C1M), type II (C2M), type III (C3M) and type IV (C4M2) were quantified by enzyme-linked immunosorbent assay (ELISA). All metabolites were higher in axSpA than in controls (all p < 001). Serum levels of C1M, C3M, and C4M2 were increased in AS compared to nr-axSpA (43 ng/mL vs. 34; p < 001, 15 vs. 12; p = 001, and 27 vs. 22; p < 001). ordinary cleanser to differentiate between axSpA and controls was C3M (AUC 05; specificity 92, sensitivity 83). C1M correlated with ASDAS-CRP in nr-axSpA (ρ = 07; p < 001) and AS (ρ = 07; p < 001). C1M, C3M, and C4M2 were associated with ASDAS-CRP in AS and nr-axSpA after adjustment for age, gender, and disease duration. Serum levels of collagen metabolites were significantly higher in AS and nr-axSpA than in controls. Moreover, the present study indicates that collagen metabolites reflect disease activity and are useful biomarkers of Conflict of interest statement: A.S.S. and A. C.B.J. are full-time employees of Nordic Bioscience, which is a privately-owned SME that develops biomarkers of fibrosis. A.C.B. J. is also a stockholder of Nordic Bioscience. The authors have no other relevant affiliation or financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those previously disclosed. No writing assistance was used in the production of this manuscript. All authors of the Institute of Rheumatology (M.H., S. F., K.Z., M.T., M.G. , K.B., J.H., J.G. and K. P.) declare no competing interest in this study. All authors declare no non-financial conflicts regarding to this study.Nonablative facial remodeling: erythema reduction and histologic evidence of new collagen formation using a 300-microsecond 1064-nm Nd:YAG laser.BACKGROUND: A variety of nonablative lasers have been used to improve skin color and toning. what is squalane of new collagen has been seen.